MTI Recommendations for PMID: 9346183
(Updated: March 14, 2007)

PMID- 9346183
TI - Solitary fibrous tumor of soft tissue: a report of 15 cases, including 5 malignant examples with light microscopic, immunohistochemical, and ultrastructural data.
AB - We describe 15 soft tissue solitary fibrous tumors (SFTs) occurring in patients 24 to 78 years old (average, 50.6 yr). Ten tumors were benign and arose in the head and neck area (three tumors), thigh (two), vulva (two), upper arm (one), lower leg (one), and retroperitoneum (one). Five tumors were histologically malignant and arose in the thigh (two), abdominal wall (one), buttock (one), and retroperitoneum (one). All of the tumors were grossly well circumscribed. The benign tumors measured from 2 to 10 cm (average, 4.8 cm) and the malignant ones from 3 to 5.5 cm (average, 4.3 cm) in greatest diameter. Microscopically, the benign tumors showed areas of hypercellularity with variable amounts of collagenous and myxoid stroma; one had amianthoid fibers. The malignant tumors were composed of cytologically atypical cells enmeshed in a collagenous or myxoid extracellular matrix. Ultrastructural study of three benign and three malignant tumors showed fibroblastic differentiation; one benign tumor showed myofibroblastic differentiation. Immunohistochemically, all of the tumors examined were immunoreactive for vimentin, and seven of nine were positive for CD34, including all of the malignant ones. There was focal staining for muscle actin in two benign tumors and for Leu-7 in one benign tumor; there was no staining for cytokeratin, desmin, S-100 protein, epithelial membrane antigen, or smooth muscle actin in any of the examined tissues. Follow-up was available for eight patients for 6 to 21 months (average, 12 mo). No tumor recurred locally or metastasized. The SFTs reported herein support the experiences of others who recently described these tumors in the somatic soft tissues. In addition, our series highlights the occurrence of malignant SFTs in the soft tissues. SFTs should be separated from other spindle cell sarcomas, with which they can be confused.

Right Wrong Missed Precision Recall F-Measure
5 17 13 0.2273 0.2778 0.2500
 
Manual MTI
Abdominal Muscles
Adult
Aged
Buttocks
Cell Nucleus
Endoplasmic Reticulum, Rough
Extremities
Female [CT]
*Fibroma [7]
Head and Neck Neoplasms
Humans [CT]
Immunohistochemistry [8]
Male
Middle Aged
Retroperitoneal Neoplasms
*Soft Tissue Neoplasms [5]
Tumor Markers, Biological
Vulvar Neoplasms
 *Neoplasms, Fibrous Tissue (MM;RC)
*Phototherapy (MM)
*Light (MM)
Sarcoma (MM;RC)
Soft Tissue Neoplasms (RC)
Fibroma, Desmoplastic (RC)
Fibroma (RC)
Immunohistochemistry (RC)
Antigens, CD34 (MM;RC)
Microscopy, Electron (RC)
Muscle Neoplasms (RC)
Fibrosarcoma (RC)
Lipoma (RC)
Neoplasms (MM)
*Drug Administration Routes (MM)
Nerve Sheath Neoplasms (RC)
*Musculoskeletal System (MM)
Desmin (MM;RC)
Abdominal Neoplasms (RC)
Thoracic Neoplasms (RC)
Humans (CT)
Female (CT)